Chronological order

2010

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.

Klareskog L, Malmström V, Lundberg K, Padyukov L, Alfredsson L.

Semin Immunol. 2011 Mar 2. [Epub ahead of print]

Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis.

D'Amato M, Zucchelli M, Seddighzadeh M, Anedda F, Lindblad S, Kere J, Alfredsson L, Klareskog L, Padyukov L.

PLoS One. 2010 Feb 22;5(2):e9315.

Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.

Seddighzadeh M, Korotkova M, Källberg H, Ding B, Daha N, Kurreeman FA, Toes RE, Huizinga TW, Catrina AI, Alfredsson L, Klareskog L, Padyukov L.

Eur J Hum Genet. 2010 Feb 24. [Epub ahead of print]

Protection from ACPA-positive rheumatoid arthritis (RA) is predominantly associated with HLA-DRB1*1301: "A meta-analysis of HLA-DRB1 associations with ACPA-positive and ACPA-negative RA in four European populations"

van der Woude D, Lie BA, Lundström E, Balsa A, Feitsma AL, Houwing-Duistermaat JJ, Verduyn W, Nordang GB, Alfredsson L, Klareskog L, Pascual-Salcedo D, Gonzalez-Gay MA, Lopez-Nevot MA, Valero F, Roep BO, Huizinga TW, Kvien TK, Martín J, Padyukov L, de Vries RR, Toes RE.

Arthritis Rheum. 2010 Jan 29. [Epub ahead of print]

2009

Silica exposure among male current smokers is associated with a high risk of developing ACPA positive rheumatoid arthritis.

Stolt P, Yahya A, Bengtsson C, Källberg H, Rönnelid J, Lundberg I, Klareskog L, Alfredsson L, Study Group TE.

Ann Rheum Dis. 2009 Dec 4. [Epub ahead of print]

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P; YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.

Nat Genet. 2009 Dec;41(12):1313-8. Epub 2009 Nov 8.

Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.

Mahdi H, Fisher BA, Källberg H, Plant D, Malmström V, Rönnelid J, Charles P, Ding B, Alfredsson L, Padyukov L, Symmons DP, Venables PJ, Klareskog L, Lundberg K.

Nat Genet. 2009 Dec;41(12):1319-1324. Epub 2009 Nov 8.

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

International MHC and Autoimmunity Genetics Network, Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18680-5. Epub 2009 Oct 21.

No increased occurrence of ischemic heart disease prior to the onset of rheumatoid arthritis: results from two Swedish population-based rheumatoid arthritis cohorts.

Holmqvist ME, Wedrén S, Jacobsson LT, Klareskog L, Nyberg F, Rantapää-Dahlqvist S, Alfredsson L, Askling J.

Arthritis Rheum. 2009 Oct;60(10):2861-9.

Dietary Fish and Fish Oil and the Risk of Rheumatoid Arthritis.

Rosell M, Wesley AM, Rydin K, Klareskog L, Alfredsson L; the EIRA study group.

Epidemiology. 2009 Aug 27. [Epub ahead of print]

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important.

Lundström E, Källberg H, Alfredsson L, Klareskog L, Padyukov L.

Arthritis Rheum. 2009 Jun;60(6):1597-603.

Patients' conceptions of the cause of their rheumatoid arthritis: A qualitative study.

Bergsten U, Bergman S, Fridlund B, Alfredsson L, Berglund A, Petersson IF, Arvidsson B; the EIRA Study Group.

Musculoskeletal Care. 2009 May 18. [Epub ahead of print]

Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis.

Hueber W, Tomooka BH, Batliwalla F, Li W, Monach PA, Tibshirani RJ, Van Vollenhoven RF, Lampa J, Saito K, Tanaka Y, Genovese MC, Klareskog L, Gregersen PK, Robinson WH.

Arthritis Res Ther. 2009;11(3):R76. Epub 2009 May 21.

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.

Lee YC, Raychaudhuri S, Cui J, de Vivo I, Ding B, Alfredsson L, Padyukov L, Costenbader KH, Seielstad M, Graham RR, Klareskog L, Gregersen PK, Plenge RM, Karlson EW.

Arthritis Rheum. 2009 May;60(5):1250-4.

Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.

Lundström E, Källberg H, Smolnikova M, Ding B, Rönnelid J, Alfredsson L, Klareskog L, Padyukov L.

Arthritis Rheum. 2009 Apr;60(4):924-30.

Psychosocial stress at work and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Bengtsson C, Theorell T, Klareskog L, Alfredsson L.

Psychother Psychosom. 2009;78(3):193-4. Epub 2009 Mar 24. No abstract available.

Environmental influences on risk for rheumatoid arthritis.

Liao KP, Alfredsson L, Karlson EW.

Curr Opin Rheumatol. 2009 May;21(3):279-83.

Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.

Liao KP, Gunnarsson M, Källberg H, Ding B, Plenge RM, Padyukov L, Karlson EW, Klareskog L, Askling J, Alfredsson L.

Arthritis Rheum. 2009 Mar;60(3):653-60.

On the origins of complex immune-mediated disease: the example of rheumatoid arthritis.

Klareskog L, Wedrén S, Alfredsson L.

J Mol Med. 2009 Apr;87(4):357-62. Epub 2009 Jan 22.

Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.

Ding B, Padyukov L, Lundström E, Seielstad M, Plenge RM, Oksenberg JR, Gregersen PK, Alfredsson L, Klareskog L.

Arthritis Rheum. 2009 Jan;60(1):30-8.

Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies.

Källberg H, Jacobsen S, Bengtsson C, Pedersen M, Padyukov L, Garred P, Frisch M, Karlson EW, Klareskog L, Alfredsson L.

Ann Rheum Dis. 2009 Feb;68(2):222-7. Epub 2008 Jun 5. Links

2008

Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.

Nat Genet. 2008 Oct;40(10):1216-23. Epub 2008 Sep 14.

Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis.

Kling A, Seddighzadeh M, Arlestig L, Alfredsson L, Rantapää-Dahlqvist S, Padyukov L.

Ann Rheum Dis. 2008 Aug;67(8):1111-5. Epub 2007 Nov 15.

Immunity to Citrullinated Proteins in Rheumatoid Arthritis. Annu Rev Immunol.

Klareskog L, Rönnelid J, Lundberg K, Padyukov L, Alfredsson L.

Annu Rev Immunol. 2008;26:651-75.

2007

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D.

Nat Genet. 2007 Dec;39(12):1477-82. Epub 2007 Nov 4.

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.

Olsson LM, Lindqvist AK, Källberg H, Padyukov L, Burkhardt H, Alfredsson L, Klareskog L, Holmdahl R.

Arthritis Res Ther. 2007;9(5):R98.

A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.

Kurreeman FA, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, Stoeken-Rijsbergen G, van der Helm-van Mil AH, Allaart CF, Verduyn W, Houwing-Duistermaat J, Alfredsson L, Begovich AB, Klareskog L, Huizinga TW, Toes RE.

PLoS Med. 2007 Sep;4(9):e278. Erratum in: PLoS Med. 2007 Dec;4(12):e358.

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, de Bakker PI, Le JM, Lee HS, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK.

N Engl J Med. 2007 Sep 6;357(10):977-86.

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Beckman EM, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK.

N Engl J Med. 2007 Sep 20;357(12):1199-209. Epub 2007 Sep 5.

Association of arthritis with a gene complex encoding C-type lectin-like receptors.

Lorentzen JC, Flornes L, Eklöw C, Bäckdahl L, Ribbhammar U, Guo JP, Smolnikova M, Dissen E, Seddighzadeh M, Brookes AJ, Alfredsson L, Klareskog L, Padyukov L, Fossum S.

Arthritis Rheum. 2007 Aug;56(8):2620-32.

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.

Sigurdsson S, Padyukov L, Kurreeman FA, Liljedahl U, Wiman AC, Alfredsson L, Toes R, Rönnelid J, Klareskog L, Huizinga TW, Alm G, Syvänen AC, Rönnblom L.

Arthritis Rheum. 2007 Jul;56(7):2202-10.

Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.

Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH, Toes RE, Huizinga TW, Klareskog L, Alfredsson L; Epidemiological Investigation of Rheumatoid Arthritis study group.

Am J Hum Genet. 2007 May;80(5):867-75. Epub 2007 Apr 2.

Smoking as a trigger for inflammatory rheumatic diseases.

Klareskog L, Padyukov L, Alfredsson L.

Curr Opin Rheumatol. 2007 Jan;19(1):49-54. Review.

2006

Genes, environment and immunity in the development of rheumatoid arthritis.

Klareskog L, Padyukov L, Rönnelid J, Alfredsson L.

Curr Opin Immunol. 2006 Dec;18(6):650-5. Epub 2006 Sep 28. Review.

Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis.

Klareskog L, Padyukov L, Lorentzen J, Alfredsson L.

Nat Clin Pract Rheumatol. 2006 Aug;2(8):425-33. Review.

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, Ronnelid J, Harris HE, Ulfgren AK, Rantapaa-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L.

Arthritis Rheum. 2006 Jan;54(1):38-46

2005

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD.

Am J Hum Genet. 2005 Dec;77(6):1044-60. Epub 2005 Nov 1.

Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study.

Sverdrup B, Kallberg H, Bengtsson C, Lundberg I, Padyukov L, Alfredsson L, Klareskog L; Epidemiological Investigation of Rheumatoid Arthritis Study Group.

Arthritis Res Ther. 2005;7(6):R1296-303. Epub 2005 Sep 23.

Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Bengtsson C, Nordmark B, Klareskog L, Lundberg I, Alfredsson L; EIRA Study Group.

Ann Rheum Dis. 2005 Nov;64(11):1588-94. Epub 2005 Apr 20.

MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.

Swanberg M, Lidman O, Padyukov L, Eriksson P, Akesson E, Jagodic M, Lobell A, Khademi M, Borjesson O, Lindgren CM, Lundman P, Brookes AJ, Kere J, Luthman H, Alfredsson L, Hillert J, Klareskog L, Hamsten A, Piehl F, Olsson T.

Nat Genet. 2005 May;37(5):486-94. Epub 2005 Apr 10.

Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study.

Stolt P, Kallberg H, Lundberg I, Sjogren B, Klareskog L, Alfredsson L; EIRA study group.

Ann Rheum Dis. 2005 Apr;64(4):582-6. Epub 2004 Aug 19.

2004

What precedes development of rheumatoid arthritis?

Klareskog L, Alfredsson L, Rantapaa-Dahlqvist S, Berglin E, Stolt P, Padyukov L.

Ann Rheum Dis. 2004 Nov;63 Suppl 2:ii28-ii31. Review.

A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.

Padyukov L, Silva C, Stolt P, Alfredsson L, Klareskog L.

Arthritis Rheum. 2004 Oct;50(10):3085-92.

Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope.

Prokunina L, Padyukov L, Bennet A, de Faire U, Wiman B, Prince J, Alfredsson L, Klareskog L, Alarcon-Riquelme M.

Arthritis Rheum. 2004 Jun;50(6):1770-3.

2003

Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases.
Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L; EIRA study group.

Ann Rheum Dis. 2003 Sep;62(9):835-41. Review.

2002

Genes and environment in arthritis: can RA be prevented?
Klareskog L, Lorentzen J, Padyukov L, Alfredsson L.

Arthritis Res. 2002;4 Suppl 3:S31-6. Epub 2002 May 9. Review.

1994

Occupation, occupational exposure to chemicals and rheumatological disease. A register based cohort study.
Lundberg I, Alfredsson L, Plato N, Sverdrup B, Klareskog L, Kleinau S.

Scand J Rheumatol. 1994;23(6):305-10.